Beneficial Immunomodulatory Effects of Fluticasone Propionate in Chlamydia pneumoniae-Infected Mice
نویسندگان
چکیده
The associations between inhaled corticosteroid (ICS) use and pulmonary infections remains controversial. Chlamydia pneumoniae (C. pneumoniae) accounts for asthma exacerbations; however, there are no data regarding ICS effects on C. infections. Thus, we investigated whether fluticasone propionate (FP) or budesonide (BUD) could affect infection in vitro vivo, focusing the possible mechanisms that lead to potential anti-chlamydial outcomes. We performed direct qPCR detect growth infected, FP-treated, BUD-treated A549 cells. Furthermore, FP BUD was administered by inhalation pneumoniae-infected mice. recoverable determined indirect immunofluorescence. Expression levels of interferon (IFN)-γ IFN-γ inducible chemokines were assessed qPCR. measured protein concentrations other cytokines potentially participate response ELISA. found treatment suppressed cells Higher gene expression observed FP-treated mice compared untreated (p < 0.0001). MIG/CXCL9 values significantly higher after inhalation. Collectively, FP, but not BUD, which likely due enhanced related responses.
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ژورنال
عنوان ژورنال: Pathogens
سال: 2021
ISSN: ['2076-0817']
DOI: https://doi.org/10.3390/pathogens10030338